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Amyloidosis

Amyloidosis is the irregular deposition of protein in organs or tissues. An protein becomes amyloid when it attains a specific structure and properties. There are various symptoms for various locations in the body where it can occur. Amyloidosis can also be inherited from parents to children.

The amyloidosis, due to its varying nature has many classifications. Major classification of amyloidosis includes Primary cutaneous amyloidosis, Secondary cutaneous amyloidosis, Primary systemic amyloidosis, Secondary systemic amyloidosis, Heredofamilial amyloidosis, and so on. These types are further divided into subtypes.

There are many ways to diagnose and analyze the amyloidosis. It is diagnosed through a lot of ways including histology, microscopic examination, examination under polarized light. Biopsies are in use to identify the amyloidosis to a much accurate and precise extent. In addition, other physical symptoms are also used to identify the amyloidosis. Bleeding beneath skin can also be seen in patients having amyloidosis. The amyloidosis is comprised of amyloidogenic protein which is much in every patient of amyloidosis.

The systemic amyloidosis affects many organs of the body depositing the proteins usually on the walls of the organ. The systemic amyloidosis influence different organ systems of a human body. On the other hand, less sever, organ specific amyloidosis targets one specific organ and the problems and diseases are occurred usually only with that organ. There are around thirty-five proteins of amyloidosis that are responsible for the diseases in human body. Other types of proteins are less severe and does not affect or affect to a lower extent, the human body.

The amyloids that are non-disease and natural include Curli E.coli Protein, Malarial coat protein, and spider silk, Mammalian melanosomes and so on. There are also proteins that damage to greater extent organ systems. The reason for damaging is the change in physical tissue architecture and disruption in natural functionalities of the organ. This in turn, creates problem that can be of any extent. In addition, the proteins of amyloids are also considered to have properties that help them aggregate in the organ system.

A lot of research is being conducted at different levels for discovering more and more about amyloidosis. Treatments and preventions are also suggested and different drugs are also being researched upon. The outcome is a healthier and normal life.

 
 
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