This disease is found to be associated with the preceded episodes of diarrhea which results in impulsive recovery. It was first defined as a syndrome in 1955 by Gasser et al. Hemolytic-Uremic Syndrome can occur to children in most cases but it can be found in adults as well. A report shows that Hemolytic-Uremic Syndrome in USA is estimated to be 21 cases per person in every a million people. Peak incident is found in children less than 5 years but rarely found in people aged 50 to 59.

Hemolytic-Uremic Syndrome is typically found in those who are of 6 months to 4 years but it can be found in anyone. There can be a number of causes for having this disease. Eating hamburger can be a rare cause, visiting zoo recently or a home relative with diarrhea condition who visits nursing home can be some causes of Hemolytic-Uremic Syndrome. In this condition, children usually present the syndrome for 4 to 6 days with an acute diarrheal problem. The onset of diarrhea with addition of mimic ulcerative colitis and various infections of enteric can be possible.

With the Hemolytic-Uremic Syndrome, many physical problems can also occur including hypertension and oliguria which are steady with renal compromise, cardiac involvement can also direct to congestive heart failure, fever can occur, involvement of ocular can make it possible to have retinal or vitreous hemorrhages and micro-infarcts in the pancreas can make it possible to cause pancreatitis. The sub-syndromes of this disease D+ HUS and D- HUS both have different impact in people. The D+ HUS is responsible for mortality in around 3% to 5% people while D- HUS can be responsible for 26% mortality. However, death can be associated with severe extra renal diseases.