The oxidative phase is for generating NADPH and another phase is of generating 5- carbon sugar/pentose. This procedure is good alternative for the glycolysis. The primary role of pentose phosphate pathway is anabolic rather than catabolic. Though, this procedure is involving oxidation of glucose. It takes place in cytosol while in plants, it occurs in plastids.
The chief outcomes through this pathway are:
In the form of NADPH, the production of reduced equivalents is used in reductive biosynthesis reactions within cells.
The outcome also results generation of erythrose-4-phosphate (E4P) which is used in synthesis procedures for amino acid in aromatic form.
The outcome will also take out ribose-5-phosphate (R5P) and it is used in nucleic acids and nucleotides.
Aromatic amino acids and nucleic acids both are important compounds used in many other products and helps in human procedures forming in bodies.
One of the uses of NADPH is to reduce oxygen stress from human beings. Hydrogen peroxide is also formed in the procedure of pentose phosphate pathway.
In the oxidative phase of pentose phosphate pathway, two molecules of NADP+ (with positive valence) are processed through reduction to form NADPH. The energy is utilized in this procedure for the conversion of glucose 6-phosephate into ribose 5-phosphate. The non oxidation three molecules of ribose 5-phosephates formed into xyloluse 5-phosephate's two molecules and one again molecule of ribose 5-phosephate. This procedure is again gone under synthesis to form two molecule of fructose 6-phosephate and one molecule of glyceraldehydes 3-phosphate.
Red blood cells are also metabolized with glycolysis, pentose phosphate pathway and few other pathways. There are some rate controlling enzymes for pentose phosphate pathways are also available. |